
Integrative Biotechnology Prof. KWEON, DAE HYUK Dr. Jaehyeon Hwang and Soyun Choi
A research team led by Professor Dae-Hyuk Kweon from the College of Biotechnology and Bioengineering at Sungkyunkwan University (co-first authors: Dr. Jaehyeon Hwang and Soyun Choi, M.S.) has introduced an innovative strategy utilizing nanodiscs to overcome the limitations of neutralizing antibodies against SARS-CoV-2. Neutralizing antibody therapeutics are effective in preventing infections caused by respiratory viruses such as SARS-CoV-2. However, their efficacy declines rapidly due to the virus's high mutation rate. This limitation is evident in the failure of many antibody therapeutics, both domestically and internationally, to neutralize emerging variants—particularly the Omicron strain—or their role in promoting resistant virus strains. Despite the global development of numerous antibody therapeutics for COVID-19 treatment, many have been discontinued due to their inefficacy against currently circulating variants. To address this challenge, the research team proposed a novel therapeutic approach using nanodiscs that bind to the Fc region of antibodies.
2025-02-11